Exploring the Association of Helicobacter pylori With Anti-intrinsic Factor and Anti-parietal Cell Antibodies in Pernicious Anemia: A Systematic Review

Pernicious anemia, historically tied to vitamin B12 malabsorption due intrinsic factor secretion impairment, has evolved in understanding, especially concerning its association with autoimmune gastritis. This systematic review dives deep into the multifaceted relationship between Helicobacter pylori (H. pylori) infection, gastritis, and presence of anti-intrinsic factors anti-parietal cell antibodies. Comprehensive database searches revealed a higher prevalence H. infection pernicious anemia patients, some studies suggesting consequential increase aforementioned Interestingly, eradication displayed potential therapeutic effects; patients showcased reductions antibody titers, improved histopathological findings, reversion atrophic changes gastric corpus. Such outcomes highlight conceivable benefits considering during evaluation management However, disparities across make direct comparisons challenging. It's essential approach role these conditions caution. Further research is warranted cement conclusions refine clinical strategies. seeks prompt new investigative avenues intricate link pylori, ultimately enhancing patient care.